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RSNA 2005 > Over 10 Years Experience of MR-guided Laser-induced ...
 

  CODE: SSJ12-01
  SESSION: Gastrointestinal (Liver Lesion Ablation)
  Over 10 Years Experience of MR-guided Laser-induced Thermotherapy (LITT) of Colorectal Carcinoma Metastases in the Liver

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PARTICIPANTS
Presenter
Martin Mack MD
Abstract Co-Author
Katrin Eichler MD
Thomas Lehnert MD
Dirk Proschek
Joern Balzer MD
Thomas Vogl MD
- Author stated no financial disclosure

- Disclosure information unavailable
  DATE: Tuesday, November 29 2005
  START TIME: 03:00 PM
  END TIME: 03:10 PM
  LOCATION: E451B

 PURPOSE
 
To evaluate long term results for MR-guided LITT for the treatment of colorectal liver metastases.
  
 METHOD AND MATERIALS
 
MR-guided LITT was performed in 839 patients (mean age 61.6 years) with 2506 liver metastases of colorectal cancer between 1993 and 2005. Survival rates were calculated using the Kaplan-Meier method. 33.3% of the lesions were 2 cm or less in diameter (mean applied energy 54.5 KJ, range 8.2-249.7 KJ), 33.3% were between 2 and 3 cm (mean applied energy 94.9 KJ, range 11.6-361.4 KJ), 18.1% were between 3 and 4 cm (mean applied energy 133.45 KJ, range 20.2-452.6 KJ), and 15.6% were larger than 4 cm in maximum diameter (mean applied energy 189.1 KJ, range 10.4-515.0 KJ). 77.6% (n=651) of the patients had 5 liver mets or less and no extrahepatic disease at the time of inclusion and were treated in curative intention. 22.4% (n=188) were treated in palliative intention (patients with more than 5 mets and/or limited extrahepatic disease). The following number of metastases was treated: 1 met in 29% of the patients, 2 mets in 26.5%, 3 mets in 17.8%, 4 mets in 10.6%, 5 mets in 7.5%, and more than 5 mets in 8,6% of the patients.
  
 RESULTS
 
The mean survival rate for all treated patients, starting the calculation at the date of diagnosis of the metastases which was treated with LITT, was 3.8 years (95% confidence interval: 3.5 - 4.1 years, 1 year survival 93%, 2 year survival 72%, 3 year survival 47%, 5 year survival 24%). Starting the calculation after the first LITT treatment the mean survival was 3.3 years (95% confidence interval: 3.0 – 3.6 years, 1 year survival 93%, 2 year survival 72%, 3 year survival 47%, 5 year survival 24%). The mean survival in the curative group was 4.0 years (95% CI: 3.7 – 4.4 years) and in the palliative group was 2.8 years (95% CI: 2.4 – 3.1 years).
  
 CONCLUSION
 
MR-guided LITT yields high local tumor control and survival rates in patients with liver metastases of colorectal carcinoma. LITT appears in surgical candidates superior to resection.
  

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